Chronic rejection: a significant role for Th17-mediated autoimmune responses to self-antigens
نویسندگان
چکیده
منابع مشابه
Role of antibodies to self-antigens in chronic allograft rejection: potential mechanism and therapeutic implications.
Significant progress has been made in preventing acute allograft rejection following solid organ transplantation resulting in improved allograft survival. However, long term function still remains disappointing primarily due to chronic allograft rejection. Alloimmune responses primarily defined by the development of antibodies (Abs) to donor mismatched major histocompatibility antigens during t...
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This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in pr...
متن کاملSelf-antigens and rejection: a proteomic analysis.
PURPOSE OF REVIEW Allo- and autoantibodies have been found to play important roles in both acute and chronic allograft rejection in organ transplantation, although only recently have non-human leukocyte antigen (non-HLA), nondonor-specific antibodies been given a more in-depth treatment. This review summarizes recent reports about investigations and proteomic approaches to identify self-antigen...
متن کاملChronic allograft rejection: A significant hurdle to transplant success
The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation. This form of rejection is responsible for long-term failure of transplanted organs. The mechanisms involved in development of chronic rejection are not well-understood. One of the main features of chronic rejec...
متن کاملTh17 cell function and Th17-mediated autoimmune disease
© 2008 Pappu et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1049-1062 www.jem.org/cgi/doi/ 1049 10.1084/jem.20071364 After activation, CD4 + Th cells diff erentiate into distinct eff ector subsets that are characterized by their unique cytokine expression and immunoregulatory function ( 1, 2 ). A novel Th subset — termed Th IL-17 , Th17, or infl ammatory Th — has bee...
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ژورنال
عنوان ژورنال: Expert Review of Clinical Immunology
سال: 2012
ISSN: 1744-666X,1744-8409
DOI: 10.1586/eci.12.58